ORCID ID: orcid.org/0000-0002-8494-7722
ResearcherID: L-9906-2014Edwards CL, Ng SS, de Labastida Rivera F, Corvino D, Engel JA, Montes de Oca M, Bukali L, Frame TCM, Bunn PT, Chauhan SB, Singh S, Wang Y, Na J, Amante FH, Loughland JR, Soon MSF, Waddell N, Mukhopadhay P, Koufariotis LT, Johnston RL, Lee JS, Kuns R, Zhang P, Boyle MJ, Hill GR, McCarthy JS, Kumar R, Engwerda CR. A molecular signature for human IL-10 producing Th1 cells in malaria. J Clin Invest. [Accepted for publication on 2022 Oct 19]
Singh SS, Chauhan SB, Ng SS, Corvino D, de Labastida Rivera F, Engel JA, Waddell N, Mukhopadhay P, Johnston RL, Koufariotis LT, Nylen S, Prakash Singh O, Engwerda CR, Kumar R, Sundar S. Increased amphiregulin expression by CD4+ T cells from individuals with asymptomatic Leishmania donovani infection. Clin Transl Immunology. 2022;11(6):e1396. doi: 10.1002/cti2.1396. eCollection 2022. PubMed PMID: 35663920; PubMed Central PMCID: PMC9136704.
Sanders C, Hamad ASM, Ng S, Hosni R, Ellinger J, Klümper N, Ritter M, Stephan C, Jung K, Hölzel M, Kristiansen G, Hauser S, Toma MI. CD103+ Tissue Resident T-Lymphocytes Accumulate in Lung Metastases and Are Correlated with Poor Prognosis in ccRCC. Cancers (Basel). 2022 Mar 17;14(6). doi: 10.3390/cancers14061541. PubMed PMID: 35326691; PubMed Central PMCID: PMC8946052.
Li XY, Corvino D, Nowlan B, Aguilera AR, Ng SS, Braun M, Cillo AR, Bald T, Smyth MJ, Engwerda CR. NKG7 Is Required for Optimal Antitumor T-cell Immunity. Cancer Immunol Res. 2022 Feb;10(2):154-161. doi: 10.1158/2326-6066.CIR-20-0649. Epub 2022 Jan 10. PubMed PMID: 35013002.
Ng SS, Leonardelli S, Hölzel M. A pan-cancer fingerprint: common molecular denominators of the human tumor microenvironment. Signal Transduct Target Ther.2021 Nov 11;6(1):394. doi: 10.1038/s41392-021-00814-x. PubMed PMID: 34764260.
Seier JA, Reinhardt J, Saraf K, Ng SS, Layer JP, Corvino D, Althoff K, Giordano FA, Schramm A, Fischer M, Hölzel M. Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma. J Immunother Cancer. 2021 May;9(5). doi: 10.1136/jitc-2020-001335. PubMed PMID: 34016720.
Guillerey C, Stannard K, Chen J, Krumeich S, Miles K, Nakamura K, Smith J, Yu Y, Ng S, Harjunpää H, Teng MW, Engwerda C, Belz GT, Smyth MJ. Systemic administration of IL-33 induces a population of circulating KLRG1hi type 2 innate lymphoid cells and inhibits type 1 innate immunity against multiple myeloma. Immunol Cell Biol. 2021 Jan;99(1):65-83. doi: 10.1111/imcb.12390. Epub 2020 Sep 18. PubMed PMID: 32748462.
Ng SS, De Labastida Rivera F, Yan J, Corvino D, Das I, Zhang P, Kuns R, Chauhan SB, Hou J, Li XY, Frame TCM, McEnroe BA, Moore E, Na J, Engel JA, Soon MSF, Singh B, Kueh AJ, Herold MJ, Montes de Oca M, Singh SS, Bunn PT, Aguilera AR, Casey M, Braun M, Ghazanfari N, Wani S, Wang Y, Amante FH, Edwards CL, Haque A, Dougall WC, Singh OP, Baxter AG, Teng MWL, Loukas A, Daly NL, Cloonan N, Degli-Esposti MA, Uzonna J, Heath WR, Bald T, Tey SK, Nakamura K, Hill GR, Kumar R, Sundar S, Smyth MJ, Engwerda CR. The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nat Immunol. 2020 Oct;21(10):1205-1218. doi: 10.1038/s41590-020-0758-6. Epub 2020 Aug 24. PubMed PMID: 32839608; PubMed Central PMCID: PMC7965849.
Kumar R, Bunn PT, Singh SS, Ng SS, Montes de Oca M, De Labastida Rivera F, Chauhan SB, Singh N, Faleiro RJ, Edwards CL, Frame TCM, Sheel M, Austin RJ, Lane SW, Bald T, Smyth MJ, Hill GR, Best SE, Haque A, Corvino D, Waddell N, Koufariotis L, Mukhopadhay P, Rai M, Chakravarty J, Singh OP, Sacks D, Nylen S, Uzonna J, Sundar S, Engwerda CR. Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis. Cell Rep. 2020 Feb 25;30(8):2512-2525.e9. doi: 10.1016/j.celrep.2020.01.099. PubMed PMID: 32101732.
Kumar R, Loughland JR, Ng SS, Boyle MJ, Engwerda CR. The regulation of CD4+ T cells during malaria. Immunol Rev. 2020 Jan;293(1):70-87. doi: 10.1111/imr.12804. Epub 2019 Nov 1. Review. PubMed PMID: 31674682.
Singh B, Bhushan Chauhan S, Kumar R, Singh SS, Ng S, Amante F, de Labastida Rivera F, Singh OP, Rai M, Nylen S, Sundar S, Engwerda C. A molecular signature for CD8+ T cells from visceral leishmaniasis patients. Parasite Immunol. 2019 Nov;41(11):e12669. doi: 10.1111/pim.12669. Epub 2019 Sep 30. PubMed PMID: 31494954.
Chauhan SB, Faleiro R, Kumar R, Ng S, Singh B, Singh OP, Singh SS, Amante F, Rivera FL, Rai M, Chakravarty J, Sacks D, Nylen S, Sundar S, Engwerda C. IL-2 is an upstream regulator of CD4+ T cells from visceral leishmaniasis patients with therapeutic potential. J Infect Dis. 2019 Feb 23. pii: jiz074. doi: 10.1093/infdis/jiz074. [Epub ahead of print] PubMed PMID: 30796820.
Kumar R, Ng S, Engwerda C. The Role of IL-10 in Malaria: A Double Edged Sword. Front Immunol. 2019 Feb 12;10:229. doi: 10.3389/fimmu.2019.00229. eCollection 2019. Review. PubMed PMID: 30809232; PubMed Central PMCID: PMC6379449.
Ng SS, Engwerda CR. Innate Lymphocytes and Malaria - Players or Spectators? Trends Parasitol. 2019 Feb;35(2):154-162. doi: 10.1016/j.pt.2018.11.012. Epub 2018 Dec 19. Review. PubMed PMID: 30579700.
Bunn PT, Montes de Oca M, de Labastida Rivera F, Kumar R, Ng SS, Edwards CL, Faleiro RJ, Sheel M, Amante FH, Frame TCM, Muller W, Haque A, Uzonna JE, Hill GR, Engwerda CR. Distinct Roles for CD4+ Foxp3+ Regulatory T Cells and IL-10-Mediated Immunoregulatory Mechanisms during Experimental Visceral Leishmaniasis Caused by Leishmania donovani. J Immunol. 2018 Dec 1;201(11):3362-3372. doi: 10.4049/jimmunol.1701582. Epub 2018 Oct 24. PubMed PMID: 30355785.
Edwards CL, de Oca MM, de Labastida Rivera F, Kumar R, Ng SS, Wang Y, Amante FH, Kometani K, Kurosaki T, Sidwell T, Kallies A, Engwerda CR. The Role of BACH2 in T Cells in Experimental Malaria Caused by Plasmodium chabaudi chabaudi AS. Front Immunol. 2018 Nov 6;9:2578. doi: 10.3389/fimmu.2018.02578. eCollection 2018. PubMed PMID: 30459773; PubMed Central PMCID: PMC6232374.
Edwards CL, Ng SS, Corvino D, Montes de Oca M, de Labastida Rivera F, Nones K, Lakis V, Waddell N, Amante FH, McCarthy JS, Engwerda CR. Early Changes in CD4+ T-Cell Activation During Blood-Stage Plasmodium falciparum Infection. J Infect Dis. 2018 Aug 24;218(7):1119-1129. doi: 10.1093/infdis/jiy281. PubMed PMID: 29757416.
Ng SS, Souza-Fonseca-Guimaraes F, Rivera FL, Amante FH, Kumar R, Gao Y, Sheel M, Beattie L, Montes de Oca M, Guillerey C, Edwards CL, Faleiro RJ, Frame T, Bunn PT, Vivier E, Godfrey DI, Pellicci DG, Lopez JA, Andrews KT, Huntington ND, Smyth MJ, McCarthy J, Engwerda CR. Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection. Clin Transl Immunology. 2018 Jan 12;7(1):e1003. doi: 10.1002/cti2.1003. eCollection 2018. PubMed PMID: 29484181; PubMed Central PMCID: PMC5822408.
Kumar R, Ng S, Engwerda C. Immunomodulation in Malaria . In: Encyclopedia of Malaria. Kremsner P, Krishna S, editors. New York, NY: Springer New York; 2018. Chapter 136-1. 1-13p
Kumar R, Chauhan SB, Ng SS, Sundar S, Engwerda CR. Immune Checkpoint Targets for Host-Directed Therapy to Prevent and Treat Leishmaniasis. Front Immunol. 2017 Nov 8;8:1492. doi: 10.3389/fimmu.2017.01492. eCollection 2017. Review. PubMed PMID: 29167671; PubMed Central PMCID: PMC5682306.
Bunn PT, Montes de Oca M, Rivera FL, Kumar R, Edwards CL, Faleiro RJ, Ng SS, Sheel M, Wang Y, Amante FH, Haque A, Engwerda CR. Galectin-1 Impairs the Generation of Anti-Parasitic Th1 Cell Responses in the Liver during Experimental Visceral Leishmaniasis. Front Immunol. 2017 Oct 12;8:1307. doi: 10.3389/fimmu.2017.01307. eCollection 2017. PubMed PMID: 29075269; PubMed Central PMCID: PMC5643427.
Gao Y, Souza-Fonseca-Guimaraes F, Bald T, Ng SS, Young A, Ngiow SF, Rautela J, Straube J, Waddell N, Blake SJ, Yan J, Bartholin L, Lee JS, Vivier E, Takeda K, Messaoudene M, Zitvogel L, Teng MWL, Belz GT, Engwerda CR, Huntington ND, Nakamura K, Hölzel M, Smyth MJ. Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells. Nat Immunol. 2017 Sep;18(9):1004-1015. doi: 10.1038/ni.3800. Epub 2017 Jul 31. PubMed PMID: 28759001.
Montes de Oca M, Kumar R, Rivera FL, Amante FH, Sheel M, Faleiro RJ, Bunn PT, Best SE, Beattie L, Ng SS, Edwards CL, Boyle GM, Price RN, Anstey NM, Loughland JR, Burel J, Doolan DL, Haque A, McCarthy JS, Engwerda CR. Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection. Cell Rep. 2016 Oct 4;17(2):399-412. doi: 10.1016/j.celrep.2016.09.015. PubMed PMID: 27705789; PubMed Central PMCID: PMC5082731.
Faleiro RJ, Kumar R, Bunn PT, Singh N, Chauhan SB, Sheel M, Amante FH, Montes de Oca M, Edwards CL, Ng SS, Best SE, Haque A, Beattie L, Hafner LM, Sacks D, Nylen S, Sundar S, Engwerda CR. Combined Immune Therapy for the Treatment of Visceral Leishmaniasis. PLoS Negl Trop Dis. 2016 Feb 12;10(2):e0004415. doi: 10.1371/journal.pntd.0004415. eCollection 2016 Feb. PubMed PMID: 26872334; PubMed Central PMCID: PMC4752322.
Montes de Oca M, Kumar R, de Labastida Rivera F, Amante FH, Sheel M, Faleiro RJ, Bunn PT, Best SE, Beattie L, Ng SS, Edwards CL, Muller W, Cretney E, Nutt SL, Smyth MJ, Haque A, Hill GR, Sundar S, Kallies A, Engwerda CR. Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology. PLoS Pathog. 2016 Jan 14;12(1):e1005398. doi: 10.1371/journal.ppat.1005398. eCollection 2016 Jan. Erratum in: PLoS Pathog. 2016 Feb;12(2):e1005460. PubMed PMID: 26765224; PubMed Central PMCID: PMC4713066.
Sheel M, Beattie L, Frame TC, de Labastida Rivera F, Faleiro RJ, Bunn PT, Montes de Oca M, Edwards CL, Ng SS, Kumar R, Amante FH, Best SE, McColl SR, Varelias A, Kuns RD, MacDonald KP, Smyth MJ, Haque A, Hill GR, Engwerda CR. IL-17A-Producing γδ T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver. J Immunol. 2015 Dec 15;195(12):5707-17. doi: 10.4049/jimmunol.1501046. Epub 2015 Nov 4. PubMed PMID: 26538396.
Engel JA, Jones AJ, Avery VM, Sumanadasa SD, Ng SS, Fairlie DP, Adams TS, Andrews KT. Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites. Int J Parasitol Drugs Drug Resist. 2015 Jun 20;5(3):117-26. doi: 10.1016/j.ijpddr.2015.05.004. eCollection 2015 Dec. PubMed PMID: 26199860; PubMed Central PMCID: PMC4506969.
Engwerda CR, Ng SS, Bunn PT. The Regulation of CD4(+) T Cell Responses during Protozoan Infections. Front Immunol. 2014 Oct 13;5:498. doi: 10.3389/fimmu.2014.00498. eCollection 2014. Review. PubMed PMID: 25352846; PubMed Central PMCID: PMC4195384.